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The Autoimmune Diseases

The Autoimmune Diseases PDF Author: Ian R. Mackay
Publisher: Academic Press
ISBN: 0123849306
Category : Medical
Languages : en
Pages : 1304

Book Description
Since publication of the 4th Edition of The Autoimmune Diseases in 2006, the understanding of the immune mechanisms underlying autoimmunity and autoimmune disease has significantly deepened and broadened. This fully revised 5th Edition incorporates new material and combines common themes underlying inductive and effector mechanisms and therapies that relate generally to the autoimmune disorders. It discusses the biological basis of disease at genetic, molecular, cellular, and epidemiologic levels and includes expanded coverage of autoinflammatory disease and autoimmune responses to tumors. Gives a thorough and an important overview on the entire field, framing individual disease chapters with information that compares and contrasts each disorder and therapy Provides thorough, up-to-date information on specific diseases, along with clinical applications, in an easily found reference for clinicians and researchers interested in certain diseases Keeps readers abreast of current trends and emerging areas in the field Ensures that content is not only up-to-date, but applicable and relevant

Autoimmune Disease

Autoimmune Disease PDF Author: Duncan Dartrey Adams
Publisher: Springer Science & Business Media
ISBN: 9400769377
Category : Medical
Languages : en
Pages : 65

Book Description
This book describes how the Jerne-Burnet Forbidden Clone Theory and the Adams-Knight H Gene Theory, solved the pathogenesis and genetics of the autoimmune diseases showing how specific immunotherapy and prophylaxis can be developed. Furthermore, Ebringer's discovery of two microbial triggers of autoimmune diseases is described and the conclusion drawn that all autoimmune diseases have microbial triggers, so will be preventable by the finding of the triggers and vaccination against them.

The Autoimmune Connection

The Autoimmune Connection PDF Author: Rita Baron-Faust
Publisher: McGraw Hill Professional
ISBN: 0071425519
Category : Health & Fitness
Languages : en
Pages : 427

Book Description
Empowers women to make informed decisions about autoimmune disorders More than 50 million Americans, most of them women, suffer from a constellation of mysterious, often misdiagnosed diseases that can result in disability, disfigurement, and death. Called "autoimmune diseases," they arise when the immune system attacks healthy tissues in almost any area of the body, and include lupus rheumatoid arthritis, Crohn's disease, scleroderma, and Graves' disease. Now Jill Buyon, a doctor working on the cutting edge of research into these diseases, and Rita Baron-Faust, an award-winning medical journalist, arm women with the knowledge they need to obtain accurate diagnoses and the best possible treatments. In The Autoimmune Connection readers learn about the recent groundbreaking discovery of the links between the different autoimmune diseases and why women are more likely to develop them. The authors offer the most up-to-date information on diagnosis, treatments, and risks for women with one or more autoimmune disease.

Autoimmune Diseases and Their Environmental Triggers

Autoimmune Diseases and Their Environmental Triggers PDF Author: Elaine A. Moore
Publisher: McFarland
ISBN: 1476602638
Category : Health & Fitness
Languages : en
Pages : 239

Book Description
Autoimmune Disease (AD) refers to any of a number of disorders caused by an immune system defect that allows the body to attack its own tissues. Some say 20 percent of the population is susceptible to Autoimmune Disease. According to current theory, individuals who develop AD do so because they are exposed to certain environmental triggers. This work is a comprehensive resource for patients with autoimmune disease. The primary focus is on the specific environmental factors, including heavy metals, hormones, organic solvents, medications, and infectious agents, that lead to autoimmune disease and that make the symptoms worse in genetically susceptible individuals. Sections of this work describe the immune system, the natural courses of disease for the various system-wide and organ-specific autoimmune disorders, and genetic factors and lifestyle influences associated with AD. Diagnostic concerns, conventional and alternative treatment options for AD, current research paths, and laboratory tests are also covered.

Autoimmune Diseases of the Skin

Autoimmune Diseases of the Skin PDF Author: Michael Hertl
Publisher: Springer Science & Business Media
ISBN: 3709137047
Category : Medical
Languages : en
Pages : 374

Book Description
Cutaneous autoimmune diseases are often chronic and severe conditions which remain an enigma for many clinicians. Experts in the field here provide a practical guide to identifying and handling these conditions. Unique in its attention to the pathophysiology, clinical diagnosis, and management of these disorders, this book is illustrated with many tables, illustrative figures and clinical color photographs. The chief aim is to broaden the understanding of the pathophysiology of cutaneous autoimmune disorders and to provide a practical guide to how to identify and manage these conditions.

Diagnostic Criteria in Autoimmune Diseases

Diagnostic Criteria in Autoimmune Diseases PDF Author: Yehuda Shoenfeld
Publisher: Springer Science & Business Media
ISBN: 1603272852
Category : Medical
Languages : en
Pages : 593

Book Description
According to the Autoimmune Diseases Coordinating Committee (ADCC), between 14.7 and 23.5 million people in the USA – up to eight percent of the population are affected by autoimmune disease. Autoimmune diseases are a family of more than 100 chronic, and often disabling, illnesses that develop when underlying defects in the immune system lead the body to attack its own organs, tissues, and cells. In Handbook of Autoimmune Disease, the editors have gathered in a comprehensive handbook a critical review, by renowned experts, of more than 100 autoimmune diseases, divided into two main groups, namely systemic and organ-specific autoimmune diseases. A contemporary overview of these conditions with special emphasis on diagnosis is presented. Each chapter contains the essential information required by attending physicians as well as bench scientists to understand the definition of a specific autoimmune disease, the diagnostic criteria, and the treatment.

Autoimmunity

Autoimmunity PDF Author: Katerina Chatzidionysiou
Publisher: BoD – Books on Demand
ISBN: 9535121340
Category : Medical
Languages : en
Pages : 212

Book Description
Autoimmunity is defined as an immune response against a self-antigen. This abnormal immune response can lead to tissue damage and to the development of autoimmune disease. From organ-specific autoimmune diseases, such as myasthenia gravis, to non-organ-specific, such as systemic lupus erythematosus, autoimmune diseases represent a heterogeneous group of disorders which affect approximately 6% of the population. The pathogenesis of many autoimmune diseases is complex and remains not completely understood. The aim of this book is to present current knowledge regarding pathogenic mechanisms of autoimmune diseases, clinical aspects of specific autoimmune diseases, like vitiligo, celiac disease and autoimmune liver disease, as well as insights regarding specific therapies.

The Molecular Biology of Autoimmune Disease

The Molecular Biology of Autoimmune Disease PDF Author: Andrew G. Demaine
Publisher: Springer Science & Business Media
ISBN: 3642751334
Category : Medical
Languages : en
Pages : 405

Book Description
Autoimmune diseases are common and often associated with considerable morbidity or - in diseases such as IDDM, myasthenia gravis and multiple sclerosis - mortality. In this volume, experts of international stature in basic science and clinical medicine with a common interest in understanding the normal and aberrant immune response present their experiences. It was their intention to fur- ther the understanding of potential clinical application of scientific observations and to help to comprehend the huge amount of results in autoimmunity research.

Biologic and Gene Therapy of Autoimmune Disease

Biologic and Gene Therapy of Autoimmune Disease PDF Author: C. Garrison Fathman
Publisher: Karger Medical and Scientific Publishers
ISBN: 3805569491
Category : Medical
Languages : en
Pages : 229

Book Description
The clinical management of autoimmune diseases has proven to be extremely difficult. Current therapies focus on trying to alleviate symptoms, but fail to correct the fundamental immune defects that lead to pathology. To achieve this goal, it is necessary to understand much of the biology of antigen presentation, lymphocyte activation and the effects of cytokines. The articles in this book provide an up-to-date review of current innovative therapies using both biologic and gene therapy for the treatment of selected autoimmune diseases. Therapeutical approaches discussed include oral tolerance, the use of anti-CD4 monoclonal antibodies, IL-10 and anti-TNFa antibodies, DNA vaccination, and gene therapy applied to organ-specific autoimmune disease. Although some of these techniques are still in their infancy, their potential efficacy has been demonstrated in several animal models of autoimmune disease, holding great promise for the future development of treatments. Written by recognized experts in the field, the chapters in this book illustrate the concept of technology transfer from bench to bedside and provide a valuable update for clinicians and scientists in clinical immunology.

Pediatrics in Systemic Autoimmune Diseases

Pediatrics in Systemic Autoimmune Diseases PDF Author: Rolando Cimaz
Publisher: Elsevier
ISBN: 0444635971
Category : Medical
Languages : en
Pages : 606

Book Description
Pediatrics in Systemic Autoimmune Diseases, Second Edition, provides a good starting point for physicians and scientists new to the field and for anyone looking for the most up-to-date summary of a particular disease. While many questions are answered, many more are raised for which we do not yet have the answers. The book provides inspiration to readers conducting their own research and helps to answer their questions. The care of children with systemic autoimmune diseases is moving forward at a rapid pace. The systemic autoimmune diseases of childhood have always represented a special problem for the physicians and scientists who care for the affected children and study their diseases. Some conditions, such as Kawasaki disease, are virtually unique to childhood, while systemic lupus erythematosus, progressive systemic sclerosis, and juvenile onset spondyloarthropathies may be thought of as the early onset of the same disease which is seen in adults. The autoinflammatory disorders appear to be of clear genetic origin, accounting for their frequent discovery in childhood. For many other conditions, such as juvenile dermatomyositis, the relationship between the conditions seen in children and that seen in adults is less certain. This book explores these phenomena, giving users a foundation on which to understand certain diseases. Includes completely updated chapters and five new chapters Explains the differences in systemic autoimmune diseases seen in children vs. those seen in adults Covers the latest advances in pathogenesis and clinical management of common conditions seen in pediatric rheumatology practices, benefiting both pediatric and adult rheumatologists, as well as physicians from other specialties Brings the reader up-to-date and allows easy access to individual topics in one place Provides the latest information available in a format that would give the clinician both a clear understanding of what has been done in the past and a scientific basis for deciding what to do for the next afflicted child in their care